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The transcriptional repression of platelet-derived growth factor receptor-beta by the zinc finger transcription factor ZNF24.

Abstract
The zinc finger transcription factor ZNF24 is a relatively uncharacterized Krüppel-like transcription factor, displaying a suppressive effect on the transcription. ZNF24 is involved in negative regulation of vascular endothelial growth factor (VEGF) and may represent a novel repressor of VEGF transcription. In a previous study, our analysis reveals that ZNF24 is a pleiotropic factor that has a role in hematopoiesis, brain development and cancers. Activation of PDGFR-beta is critically involved into various cell functions including recruitment of stromal cells and VEGF induction in tumor and perivascular cells. Here, overexpression of ZNF24 resulted in a significant down-regulation of PDGFR-beta, whereas silencing of ZNF24 with small interfering RNA led to increased PDGFR-beta expression. Overexpression of ZNF24 resulted in a significant decrease in PDGFR-beta promoter activity. These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta and may represent a novel repressor of PDGFR-beta transcription.
AuthorsJianzhong Li, Xia Chen, Ying Liu, Li Ding, Lei Qiu, Zhenlin Hu, Junping Zhang
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 397 Issue 2 Pg. 318-22 (Jun 25 2010) ISSN: 1090-2104 [Electronic] United States
PMID20510677 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCrown Copyright (c) 2010. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Kruppel-Like Transcription Factors
  • RNA, Small Interfering
  • Repressor Proteins
  • ZNF24 protein, human
  • Receptor, Platelet-Derived Growth Factor beta
Topics
  • Cell Line
  • Cell Line, Tumor
  • Down-Regulation
  • Gene Expression Regulation
  • Gene Knockdown Techniques
  • Humans
  • Kruppel-Like Transcription Factors (genetics, metabolism)
  • Promoter Regions, Genetic
  • RNA, Small Interfering (genetics)
  • Receptor, Platelet-Derived Growth Factor beta (genetics)
  • Repressor Proteins (genetics, metabolism)
  • Transcription, Genetic
  • Up-Regulation
  • Zinc Fingers

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