HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women.

Abstract

BACKGROUND:

We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women.

METHODS:

A total of 119 patients with invasive cervical squamous cell carcinoma were compared to 119 age- and menopausal status-matched non-cancer controls. Blood samples were taken from all cases and controls and lifestyle information was collected by means of a self-administered questionnaire. The estimated impact of HLA-A alleles on cervical cancer risk was evaluated by unconditional logistic regression models.

RESULTS:

The frequency of HLA-A(*)0206 among cases was significantly lower than among controls (P = 0.006). There was an inverse association between A(*)0206 and cervical cancer risk (odds ratio [OR] = 0.31, 95% confidence interval [95% CI] = 0.15 to 0.65, P = 0.002), and a positive association for HLA-A(*)2402 (OR = 1.76, 95% CI = 1.00 to 3.09, P = 0.048). After correction for multiple comparisons, A(*)0206 was significantly associated with reduced cervical cancer risk (corrected P = 0.036). Furthermore, the inverse association between A(*)0206 and cervical cancer risk was independent of smoking status (never smoker: OR = 0.37, 95% CI = 0.15 to 0.90; ever smoker: OR = 0.23, 95% CI = 0.06 to 0.89).

CONCLUSIONS:

There was an inverse association between HLA-A(*)0206 and cervical cancer risk among Japanese women, which suggests that HLA-A polymorphism influences cervical cancer risk. Further investigation in other populations is thus warranted.

• Authors: Satoyo Hosono, Takakazu Kawase, Keitaro Matsuo, Miki Watanabe, Hiroaki Kajiyama, Kaoru Hirose, Takeshi Suzuki, Kumiko Kidokoro, Hidemi Ito, Toru Nakanishi, Yasushi Yatabe, Nobuyuki Hamajima, Fumitaka Kikkawa, Kazuo Tajima, Hideo Tanaka
• Journal: Journal of epidemiology (J Epidemiol) Vol. 20 Issue 4 Pg. 295-301 ( 2010) ISSN: 1349-9092 [Electronic] Japan
• PMID: 20501960 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-A Antigens

Topics

• Adult
• Alleles
• Carcinoma, Squamous Cell (genetics)
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• HLA-A Antigens (genetics)
• Humans
• Japan
• Logistic Models
• Middle Aged
• Odds Ratio
• Polymorphism, Genetic
• Risk Factors
• Smoking
• Surveys and Questionnaires
• Uterine Cervical Neoplasms (genetics)