Abstract | BACKGROUND: DESIGN: Controlled, block-randomized study. SETTING: University research laboratory. SUBJECT: Mixed breed piglets (1-3 days, 1.5-2.3 kg). INTERVENTIONS: In acutely instrumented piglets, normocapnic alveolar hypoxia (10-15% oxygen) was induced for 2 h followed by reoxygenation with 100% oxygen (1 h) then 21% oxygen (3 h). At 2 h of reoxygenation, after volume loading ( Ringer's lactate 10 ml/kg), either saline (placebo), epinephrine (0.5 microg/kg/min), dobutamine (20 microg/kg/min) or milrinone (0.75 microg/kg/min) were infused for 2 h in a blinded, block-randomized fashion (n = 6/group). MAIN RESULTS: All medications similarly improved cardiac output, stroke volume and systemic oxygen delivery (vs. placebo-controls, p < 0.05). Epinephrine and dobutamine significantly increased, while milrinone maintained, mean arterial pressure over pretreatment values while placebo-treated piglets developed hypotension and shock. The mean arterial to pulmonary arterial pressures ratio was not different among groups. All medications significantly increased carotid and intestinal, but not renal, arterial blood flows and oxygen delivery, whereas milrinone caused lower renal vascular resistance than epinephrine and dobutamine-treated groups. Plasma troponin I, plasma and myocardial lactate levels, and histologic ischemic features were not different among groups. CONCLUSIONS:
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Authors | Chloë Joynt, David L Bigam, Gregory Charrois, Laurence D Jewell, Gregory Korbutt, Po-Yin Cheung |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 36
Issue 6
Pg. 1058-66
(Jun 2010)
ISSN: 1432-1238 [Electronic] United States |
PMID | 20221750
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bronchodilator Agents
- Cardiotonic Agents
- Dobutamine
- Milrinone
- Oxygen
- Epinephrine
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Topics |
- Animals
- Animals, Newborn
- Bronchodilator Agents
(administration & dosage, pharmacology)
- Cardiotonic Agents
(administration & dosage, pharmacology)
- Dobutamine
(administration & dosage, pharmacology)
- Epinephrine
(administration & dosage, pharmacology)
- Female
- Hypoxia
- Male
- Milrinone
(administration & dosage, pharmacology)
- Oxygen
(administration & dosage)
- Random Allocation
- Resuscitation
(methods)
- Swine
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