Abstract | PURPOSE: MATERIALS AND METHODS: This case-control study included Caucasian nonsmoking Brazilian patients with implant-supported restorations. Oral epithelial cells were taken from patients with and without peri-implantitis to evaluate the frequencies of different alleles of the TNFalpha(-308) gene by polymerase chain reaction. RESULTS: Ninety patients (49 with peri-implantitis and 41 with healthy implants) were enrolled in this study. Polymorphism in allele 2 of TNFalpha(-308) was not associated with an increased risk for peri-implantitis (P = .8171), although 14.63% of the subjects in the control group carried allele 2 and 19.39% in the peri-implantitis group carried allele 2 (chi-squared = 0.708; P = .5202). CONCLUSION: Polymorphism of the TNFalpha(-308) gene was not associated with an increased risk of peri-implantitis in the population evaluated in this study.
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Authors | Patricia R Cury, Veronica V Horewicz, Daniel S Ferrari, Rui Brito Jr, Wilson R Sendyk, Poliana M Duarte, Jamil A Shibli |
Journal | The International journal of oral & maxillofacial implants
(Int J Oral Maxillofac Implants)
2009 Nov-Dec
Vol. 24
Issue 6
Pg. 1101-5
ISSN: 0882-2786 [Print] United States |
PMID | 20162115
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dental Implants
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Aged
- Case-Control Studies
- Chi-Square Distribution
- Dental Implants
(adverse effects)
- Dental Prosthesis, Implant-Supported
- Dental Restoration Failure
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Periodontitis
(etiology, genetics)
- Polymorphism, Single Nucleotide
- Reference Values
- Tumor Necrosis Factor-alpha
(genetics)
- Young Adult
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