Predictive value of HIV type 1 DNA levels on overall survival in HIV-related lymphoma Patients treated with high-dose chemotherapy (HDC) plus autologous stem cell transplantation (ASCT).
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| Abstract |
The kinetics and predictive value of HIV-1 DNA (HIV DNA) levels in relapsed or refractory HIV lymphoma patients, treated with high-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT), were investigated. HIV DNA was measured by real-time PCR in the peripheral blood mononuclear cells (PBMCs) of 22 patients observed for a median follow-up of 31.0 months. At baseline, HIV DNA was found to be correlated with HIV-1 RNA (HIV RNA) (r = 0.56), but not with CD4(+) counts (r = -0.10). HIV RNA load was under control for the entire follow-up, while HIV DNA levels were almost always detectable (baseline levels vs. 1 year from ASCT levels, p > 0.05). Baseline HIV DNA levels were significantly different between alive and deceased patients (p = 0.03), and the overall survival (OS) analysis showed that for patients with higher HIV DNA levels at baseline there was a higher and nearly significant risk of death if compared to patients with lower levels (HR, 8.33, 95% CI, 0.99-70.06, p = 0.05). Our study demonstrated that high HIV DNA levels at baseline could predict overall survival after ASCT in one of the largest cohorts of HIV lymphoma patients treated with salvage therapy.
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| Authors | Maria Teresa Bortolin, Stefania Zanussi, Renato Talamini, Cecilia Simonelli, Chiara Pratesi, Rosamaria Tedeschi, Luciano Abbruzzese, Rosa Manuele, Maurizio Rupolo, Umberto Tirelli, Paolo De Paoli |
| Journal | AIDS research and human retroviruses (AIDS Res Hum Retroviruses) Vol. 26 Issue 2 Pg. 245-51 (Feb 2010) ISSN: 1931-8405 [Electronic] United States |
| PMID | 20156109 (Publication Type: Journal Article) |
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