Relation of Gamma-glutamyltransferase and alcohol drinking with incident diabetes: the HIPOP-OHP study.

Abstract

AIM:

Gamma-glutamyltransferase (GGT) is known to correlate well with alcohol consumption; however, the relation between GGT and diabetes and that between alcohol consumption and diabetes mellitus (DM) is inconsistent. Thus, several questions, such as whether light to moderate drinkers can be considered as low risk for diabetes incidence irrespective of their GGT level, is unresolved. In this study, we investigated the relation of GGT or alcohol drinking with DM incidence considering the body mass index (BMI) in healthy Japanese workers.

METHODS:

We followed 3095 men who did not have DM at baseline for 4 years. Incident diabetes was defined as a fasting (non-fasting) plasma glucose level of >or=7.0 (11.1) mmol/L, or treatment of diabetes. Multiple adjusted hazard ratios (HR) were calculated using Cox proportional models.

RESULTS:

Participants with higher GGT (GGT >or=27 IU/L) showed an increased risk of diabetes incidence even when their BMI level was low. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers (alcohol <23 g/day) was not low if they were either overweight (BMI >or=25 kg/m(2)) or had higher GGT (HR=2.60, p=0.08) or both overweight and higher GGT (HR=3.16, p=0.07) compared with never drinkers without higher GGT and overweight.

CONCLUSIONS:

Higher GGT was associated with a higher incidence of DM irrespective of drinking status or obesity. Although a U-shaped relation between alcohol drinking and incident diabetes was observed, the risk to light to moderate drinkers was not low if they were either overweight or had higher GGT.

• Authors: Atsushi Hozawa, Tomonori Okamura, Taichiro Tanaka, Katsuyuki Miura, Yuriko Kikuchi, Takashi Kadowaki, Katsushi Yoshita, Toru Takebayashi, Junko Tamaki, Junko Minai, Takayo Tada, Nagako Chiba, Akira Okayama, Hirotsugu Ueshima
• Journal: Journal of atherosclerosis and thrombosis (J Atheroscler Thromb) Vol. 17 Issue 2 Pg. 195-202 (Feb 26 2010) ISSN: 1880-3873 [Electronic] Japan
• PMID: 20150721 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• gamma-Glutamyltransferase

Topics

• Adult
• Alcohol Drinking
• Blood Glucose (metabolism)
• Body Mass Index
• Diabetes Mellitus (diagnosis, enzymology, etiology)
• Fasting
• Female
• Follow-Up Studies
• Humans
• Japan
• Male
• Middle Aged
• Occupational Health
• Proportional Hazards Models
• Risk Factors
• gamma-Glutamyltransferase (metabolism)