Abstract | AIMS: METHODS: RESULTS:
Uremia increased LV weight and cardiomyocyte size. Enalapril and enalapril + sevelamer blunted the increase in left ventricular weight. Only enalapril + sevelamer diminished the increase in cardiomyocyte size. Uremia increased cyclin D2 and PCNA and decreased p27 protein expression in the heart. Enalapril + sevelamer diminished the decrease in p27 expression caused by uremia. Uremia increased Ki67-positive and phosphohistone H(3)-positive interstitial cells. This was not seen in cardiomyocytes. Multivariable regression analysis showed that increased phosphorus was an independent risk factor for both increased LV weight and cardiomyocyte size. CONCLUSIONS: These data suggest left ventricular remodeling consists of cardiomyocyte hypertrophy and interstitial cell proliferation, but not cardiomyocyte proliferation. p27 and cyclin D2 may play important roles in the development of LVH. In addition, phosphorus can be an independent risk factor for the development of LVH.
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Authors | Hironori Nakamura, Masanori Tokumoto, Masahide Mizobuchi, Cynthia S Ritter, Jane L Finch, Masanori Mukai, Eduardo Slatopolsky |
Journal | American journal of nephrology
(Am J Nephrol)
Vol. 31
Issue 4
Pg. 292-302
( 2010)
ISSN: 1421-9670 [Electronic] Switzerland |
PMID | 20130393
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | 2010 S. Karger AG, Basel. |
Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Cell Cycle Proteins
- Polyamines
- Enalapril
- Sevelamer
|
Topics |
- Angiotensin-Converting Enzyme Inhibitors
(administration & dosage)
- Animals
- Cell Cycle Proteins
(physiology)
- Enalapril
(administration & dosage)
- Female
- Hypertrophy, Left Ventricular
(etiology, pathology, prevention & control)
- Myocytes, Cardiac
(pathology)
- Polyamines
(administration & dosage)
- Rats
- Rats, Sprague-Dawley
- Sevelamer
- Uremia
(complications)
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