Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop.

Abstract

Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented.

• Authors: Pataje G S Prasanna, William F Blakely, Jean-Marc Bertho, John P Chute, Eric P Cohen, Ronald E Goans, Marcy B Grace, Patricia K Lillis-Hearne, David C Lloyd, Ludy C H W Lutgens, Viktor Meineke, Natalia I Ossetrova, Alexander Romanyukha, Julie D Saba, Daniel J Weisdorf, Andrzej Wojcik, Eduardo G Yukihara, Terry C Pellmar
• Journal: Radiation research (Radiat Res) Vol. 173 Issue 2 Pg. 245-53 (Feb 2010) ISSN: 1938-5404 [Electronic] United States
• PMID: 20095857 (Publication Type: Congress, Research Support, N.I.H., Extramural)

Chemical References

• Biomarkers

Topics

• Biomarkers (analysis)
• Humans
• Radiation Injuries (diagnosis, genetics, therapy)