First- and second-line drug resistance patterns among previously treated tuberculosis patients in India.

Abstract

Culture and drug susceptibility testing results of 2816 tuberculosis (TB) patients from across India who had failed repeated treatments from 2001 to 2004 were retrospectively analysed at the Tuberculosis Research Centre, Chennai. Of 1498 (53%) identified as having multidrug-resistant TB (MDR-TB), 671 (44.8%) were resistant to > or =1 second-line drugs (SLDs): 490 (32.7%) to ethionamide, 245 (16.4%) to ofloxacin and 169 (11.3%) to kanamycin; 69 (4.6%) were extensively drug-resistant TB (XDR-TB). Although from a highly select and non-representative patient group, such high SLD resistance levels, including XDR-TB, among MDR-TB patients is of concern. The prevention of MDR/XDR-TB through quality DOTS services, however, remains the priority. In addition, rapid scale-up of quality programmatic management under the RNTCP is needed, with more control and rational use of SLDs outside the programme.

• Authors: C N Paramasivan, F Rehman, F Wares, N Sundar Mohan, S Sundar, S Devi, P R Narayanan
• Journal: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease (Int J Tuberc Lung Dis) Vol. 14 Issue 2 Pg. 243-6 (Feb 2010) ISSN: 1815-7920 [Electronic] France
• PMID: 20074419 (Publication Type: Journal Article)

Chemical References

• Antitubercular Agents

Topics

• Antitubercular Agents (administration & dosage, pharmacology)
• Directly Observed Therapy (methods)
• Extensively Drug-Resistant Tuberculosis (epidemiology, microbiology, prevention & control)
• Humans
• India (epidemiology)
• Microbial Sensitivity Tests
• Mycobacterium tuberculosis (drug effects, isolation & purification)
• Retrospective Studies
• Treatment Failure
• Tuberculosis, Multidrug-Resistant (epidemiology, microbiology, prevention & control)