Transarterial chemoembolization as initial treatment for unresectable hepatocellular carcinoma in southern China.

Abstract

AIM:

To identify prognostic factors from pretreatment variables of the initial transarterial chemoembolization (TACE) procedure in unresectable hepatocellular carcinoma (HCC).

METHODS:

One thousand and five hundred and sixty-nine patients with unresectable HCC underwent TACE as initial treatment were retrospectively studied. Pretreatment variables of the initial TACE procedure with a P value less than 0.05 by univariate analysis were subjected to Cox proportional hazards model.

RESULTS:

The median overall survival time and 1-, 5-, 10-year survival rates were 10.37 mo, 47%, 10%, and 7%, respectively. A Cox proportional hazard model showed that 8 pretreatment factors of regional lymph nodes metastasis, Child-Pugh class, macrovascular invasion, greatest dimension, alpha-fetoprotein (AFP), Hepatitis virus B, tumor capsule, and nodules were independent prognostic factors. Patients with multimodality therapy have better survival than those with TACE treatment only.

CONCLUSION:

Tumor status, hepatic function reserve, AFP, and hepatitis virus B status were independent prognostic factors for unresectable HCC. Distant metastasis might not be a contraindication to TACE. Multimodality therapy might improve survival.

• Authors: Ming Shi, Ji-An Chen, Xiao-Jun Lin, Rong-Ping Guo, Yun-Fei Yuan, Min-Shan Chen, Ya-Qi Zhang, Jin-Qing Li
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 16 Issue 2 Pg. 264-9 (Jan 14 2010) ISSN: 2219-2840 [Electronic] United States
• PMID: 20066748 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• alpha-Fetoproteins

Topics

• Adult
• Carcinoma, Hepatocellular (diagnosis, epidemiology, therapy)
• Chemoembolization, Therapeutic
• China (epidemiology)
• Female
• Hepatitis B virus (isolation & purification)
• Humans
• Liver (physiopathology)
• Liver Neoplasms (diagnosis, epidemiology, therapy)
• Male
• Middle Aged
• Prognosis
• Proportional Hazards Models
• Retrospective Studies
• Survival Rate
• Treatment Outcome
• alpha-Fetoproteins (metabolism)