Neonatal alloimmune thrombocytopenia caused by anti-HLA-A24 alloantibodies.

Abstract

UNLABELLED:

Neonatal alloimmune thrombocytopenia (NAIT) occurs as a result of maternal alloimmunization against paternally inherited antigens on foetal platelets. Platelets express platelet specific antigens (HPA) along with human leucocyte antigens (HLA) class I. Although anti-HLA class I antibodies are often detectable in pregnant women, their role in NAIT is considered controversial. We report a case of NAIT where the most sensitive serological analysis and molecular methods could not detect platelet specific antibodies. Only HLA incompatibility and presence of anti-HLA-A24 antibodies in both the mother's and the newborn's serum were proven.

CONCLUSION:

This case supports the idea that some anti-HLA class I antibodies could cause NAIT.

• Authors: M Starcevic, M Tomicic, M Malenica, V Zah-Matakovic
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 99 Issue 4 Pg. 630-2 (Apr 2010) ISSN: 1651-2227 [Electronic] Norway
• PMID: 19912145 (Publication Type: Case Reports, Journal Article)

Chemical References

• HLA-A Antigens
• HLA-A24 Antigen
• Isoantibodies

Topics

• Blood Platelets (immunology)
• Female
• HLA-A Antigens (immunology)
• HLA-A24 Antigen
• Humans
• Infant, Newborn
• Isoantibodies (blood)
• Maternal-Fetal Exchange (immunology)
• Platelet Count
• Pregnancy
• Thrombocytopenia, Neonatal Alloimmune (blood, diagnosis, immunology)
• Young Adult