The effects of ciprofloxacin and ursodeoxycholic acid on bacterial translocation in obstructive jaundice.

Abstract

BACKGROUND/AIMS:

We aimed to search the effects of two different drugs in bacterial translocation, both in combination and alone: ursodeoxycholic acid, the effectiveness of which was evidenced previously, and ciprofloxacin, which had not been used before, in an experimental obstructive jaundiced rat model.

METHODS:

Fifty Wistar Albino rats were divided into five groups: sham group (A), control group (B), ciprofloxacin group (C), ursodeoxycholic acid group (D), and ciprofloxacin + ursodeoxycholic acid group (E). Except in Group A animals, the common bile ducts in all animals were ligated. Hematological, microbiological and histopathological changes were compared between the groups.

RESULTS:

White blood cell counts were elevated in all common bile duct-ligated test subjects. The median white blood cell count in Group B was significantly higher than that in Group D and Group E (p=0.022 and p=0.037, respectively). There was no significant difference between the control group and the study groups in terms of biochemical changes. Blood cultures were negative in Group A and Group E. The positive blood culture rate in Group B was significantly higher than in Groups A and E (p<0.05). Positive mesenteric lymph node culture rate was significantly lower in Group E than in the control group (p=0.026). In the histopathological evaluation, there was no difference in the morphology of the terminal ileum between the groups, but Group E animals had significantly less inflammatory cells in the intestinal wall compared to Group C and D animals.

CONCLUSIONS:

Ciprofloxacin and ursodeoxycholic acid have a synergic effect on prevention of bacterial translocation in obstructive jaundice.

• Authors: Oskay Kaya, Fatih Ozdemir, Mesut Atli, Volkan Aslan, Mustafa Cağatay, Murat Anlar, Murat Alper
• Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (Turk J Gastroenterol) Vol. 20 Issue 3 Pg. 186-91 (Sep 2009) ISSN: 2148-5607 [Electronic] Turkey
• PMID: 19821200 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Cholagogues and Choleretics
• Ciprofloxacin
• Ursodeoxycholic Acid

Topics

• Animals
• Anti-Infective Agents (pharmacology)
• Bacterial Translocation (drug effects)
• Cholagogues and Choleretics (pharmacology)
• Ciprofloxacin (pharmacology)
• Drug Synergism
• Female
• Gram-Negative Bacterial Infections (drug therapy)
• Gram-Positive Bacterial Infections (drug therapy)
• Jaundice, Obstructive (drug therapy, microbiology)
• Leukocyte Count
• Rats
• Rats, Wistar
• Ursodeoxycholic Acid (pharmacology)