Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging study.

Abstract

Insomnia afflicts many individuals, but particularly those in chronic methadone treatment. Studies examining sleep deprivation (SD) have begun to identify sleep restoration processes involving brain bioenergetics. The technique ([31])P magnetic resonance spectroscopy (MRS) can measure brain changes in the high-energy phosphates: alpha-, beta-, and gamma-nucleoside triphosphate (NTP). In the present study, 21 methadone-maintained (MM) and 16 control participants underwent baseline (BL), SD (40 wakeful hours), recovery1 (RE1), and recovery2 (RE2) study nights. Polysomnographic sleep was recorded each night and ([31])P MRS brain scanning conducted each morning using a 4T MR scanner (dual-tuned proton/phosphorus head-coil). Interestingly, increases in total sleep time (TST) and sleep efficiency index (SEI) commonly associated with RE sleep were not apparent in MM participants. Analysis of methadone treatment duration revealed that the lack of RE sleep increases in TST and SEI was primarily exhibited by short-term MM participants (methadone <12 months), while RE sleep in long-term MM (methadone >12 months) participants was more comparable to control participants. Slow wave sleep increased during RE1, but there was no difference between MM and control participants. Spectral power analysis revealed that compared to control participants; MM participants had greater delta, theta, and alpha spectral power during BL and RE sleep. ([31])P MRS revealed that elevations in brain beta-NTP (a direct measure of ATP) following RE sleep were greater in MM compared to control participants. Results suggest that differences in sleep and brain chemistry during RE in MM participants may be reflective of a disruption in homeostatic sleep function.

• Authors: George H Trksak, J Eric Jensen, David T Plante, David M Penetar, Wendy L Tartarini, Melissa A Maywalt, Michael Brendel, Cynthia M Dorsey, Perry F Renshaw, Scott E Lukas
• Journal: Drug and alcohol dependence (Drug Alcohol Depend) Vol. 106 Issue 2-3 Pg. 79-91 (Jan 15 2010) ISSN: 1879-0046 [Electronic] Ireland
• PMID: 19775835 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Methadone

Topics

• Adult
• Brain (physiology, physiopathology)
• Drug Administration Schedule
• Electrocardiography
• Electroencephalography (methods)
• Electrooculography
• Homeostasis
• Humans
• Magnetic Resonance Spectroscopy (methods)
• Methadone (adverse effects, therapeutic use)
• Middle Aged
• Sleep (physiology)
• Sleep Deprivation (chemically induced, physiopathology)
• Young Adult