Abstract |
Granulocyte colony stimulating factor (GCSF) may boost physiological stem cell repair system in patients with cerebral lesions. Atypical parkinsonisms (PSP, CBD, MSA) are characterized by rapidly progressive course without significant benefit from current therapies. We treated 11 patients with atypical parkinsonism (MSA n=4, PSP n=5, CBD n=2) with GCSF (5mcg/kg s.c. daily for 6 days/month) for 3 months. We assessed CBC, CD34+ cells, routine biochemical and coagulation tests, UPDRS motor scores and safety. We did not observe significant adverse events during and following GCSF treatment. One patient withdrew informed consent. Three patients complained about bone pain that improved following steroid treatment. Four patients perceived a subjective benefit after treatment was completed. UPDRS motor score improved in three patients, remained stable in two and worsened in five. GCSF can be safely administered to patients with atypical parkinsonism and potentially meaningful clinical changes may be observed in some patients. These results are encouraging and warrant further studies.
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Authors | Gianni Pezzoli, Silvana Tesei, Margherita Canesi, Giorgio Sacilotto, Montefusco Vittorio, Yoshi Mizuno, Hideki Mochizuki, Angelo Antonini |
Journal | Clinical neurology and neurosurgery
(Clin Neurol Neurosurg)
Vol. 112
Issue 1
Pg. 65-7
(Jan 2010)
ISSN: 1872-6968 [Electronic] Netherlands |
PMID | 19765889
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | 2009 Elsevier B.V. All rights reserved. |
Chemical References |
- Antigens, CD34
- Granulocyte Colony-Stimulating Factor
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Topics |
- Aged
- Antigens, CD34
(blood)
- Female
- Granulocyte Colony-Stimulating Factor
(adverse effects, therapeutic use)
- Hematopoietic Stem Cell Mobilization
(adverse effects)
- Humans
- Leukocyte Count
- Male
- Middle Aged
- Multiple System Atrophy
(therapy)
- Nerve Degeneration
(therapy)
- Neurologic Examination
- Parkinson Disease
(therapy)
- Supranuclear Palsy, Progressive
(therapy)
- Treatment Outcome
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