Protein kinase Calpha puts the hand cuffs on epidermal keratinocyte proliferation.

Abstract

As the predominant cellular receptor for phorbol esters, protein kinase C (PKC) is assumed to play a role in epidermal carcinogenesis. Nevertheless, determining its exact role in keratinocytes has been difficult because of the existence of multiple PKC isoforms and the inherent weaknesses in methodologies used to investigate their function. In this issue, Jerome-Morais et al. describe their use of multiple in vitro, in situ, overexpression, and knockdown approaches to demonstrate that PKCalpha induces keratinocyte growth arrest.

• Authors: Wendy B Bollag
• Journal: The Journal of investigative dermatology (J Invest Dermatol) Vol. 129 Issue 10 Pg. 2330-2 (Oct 2009) ISSN: 1523-1747 [Electronic] United States
• PMID: 19749780 (Publication Type: Journal Article, Comment)

Chemical References

• Isoenzymes
• Protein Kinase C-alpha

Topics

• Cell Cycle (physiology)
• Cell Differentiation (physiology)
• Cell Membrane (enzymology, physiology)
• Cell Proliferation
• Epidermal Cells
• Epidermis (enzymology, physiology)
• Humans
• Isoenzymes (physiology)
• Keratinocytes (cytology, enzymology, physiology)
• Protein Kinase C-alpha (physiology)