Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes.

Abstract

There are few data on circulatory pro-inflammatory cytokine levels and cytokine gene polymorphisms in H. pylori-positive patients. A cross-sectional study was conducted to examine the effects of H. pylori infection, gastric atrophy, and the IL-8 T-251A polymorphism on plasma IL-8 levels in 98 Japanese adults. Seventy-one subjects were positive for H. pylori infection. The geometric mean of plasma IL-8 concentration was significantly higher in subjects with H. pylori infection than in those without (P=0.001). The development of atrophy was negatively associated with IL-8 levels in the H. pylori-positive subjects, although not significantly. Plasma IL-8 levels in the T/T genotype were associated with H. pylori infection and atrophy status (P=0.016). Our findings suggested that circulating IL-8 levels were associated with H. pylori infection. The effect of H. pylori infection on plasma IL-8 levels was not clearly modified by the IL-8 T-251A polymorphism.

• Authors: M Naito, H Eguchi, Y Goto, T Kondo, K Nishio, Y Ishida, S Kawai, R Okada, A Hishida, K Wakai, N Hamajima
• Journal: Epidemiology and infection (Epidemiol Infect) Vol. 138 Issue 4 Pg. 512-8 (Apr 2010) ISSN: 1469-4409 [Electronic] England
• PMID: 19719901 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-8

Topics

• Adult
• Aged
• Atrophy
• Cross-Sectional Studies
• Female
• Gastric Mucosa (pathology)
• Genotype
• Helicobacter Infections (genetics, immunology, pathology)
• Helicobacter pylori (immunology)
• Humans
• Interleukin-8 (blood, genetics)
• Japan
• Male
• Middle Aged
• Polymorphism, Genetic
• Young Adult