Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135).

Abstract

Severe acute hepatitis of unknown etiology is difficult to treat and often progresses to subacute fulminant hepatitis or late-onset hepatic failure. A 45-year-old well-nourished, healthy man had progressive fatigue and his liver function tests showed severe liver dysfunction. The etiology of sever acute cholestatic hepatitis was unknown. The liver function tests normalized gradually, which excluded high persistent total bilirubin after starting on predonine. A liver biopsy showed chronic active hepatitis with mild fibrosis (A2, F1). Oral Inchinko-to, a Chinese herbal medicine, at 7.5 g daily was prescribed. The treatment was effective with no adverse effects. We present a successfully treated case and discuss hepatoprotective and choleretic effects of Inchinko-to.

• Authors: Susumu Ohwada, Isao Kobayashi, Nobuo Harasawa, Kyoichiro Tsuda, Yosikatsu Inui
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 15 Issue 23 Pg. 2927-9 (Jun 21 2009) ISSN: 2219-2840 [Electronic] United States
• PMID: 19533820 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cholagogues and Choleretics
• Drugs, Chinese Herbal
• inchinko-to

Topics

• Cholagogues and Choleretics (therapeutic use)
• Cholestasis, Intrahepatic (drug therapy, etiology)
• Drugs, Chinese Herbal
• Gallbladder (pathology)
• Humans
• Liver Function Tests
• Male
• Medicine, Chinese Traditional
• Middle Aged
• Treatment Outcome