Management of sorafenib, sunitinib, and temsirolimus toxicity in metastatic renal cell carcinoma.

Abstract

PURPOSE OF REVIEW:

To review the common and serious toxicities associated with the use of tyrosine kinase inhibitors such as sorafenib and sunitinib and mTOR inhibitor temsirolimus, and to outline the most recent toxicity management guidelines.

RECENT FINDINGS:

Common grade 3 or 4 side effects with sorafenib include lymphopenia (13%), hypophosphatemia (13%), elevated lipase (12%), hand-foot syndrome (6%), and mucositis/stomatitis (6%). Common grade 3 or 4 side effects with suntinib elevated lipase (16%), neutropenia (12%), lymphopenia (12%), hypertension (8%), and fatigue/asthenia (7%). As for temsirolimus, common grade 3 or 4 side effects consist of anemia (20%), hyperglycemia (11%), fatigue/asthenia (11%), dyspnea (9%), and hypophosphatemia (5%). Intracranial hemorrhage (ICH) is rare but occurred in sorafenib-exposed and sunitinb-exposed patients. Cardiovascular morbidity may also be observed in sorafenib-exposed and sunitinib-exposed patients.

SUMMARY:

Through preventive and therapeutic measures, these side effects can be effectively managed, without reducing the dose and, therefore, affecting the efficacy of the treatment.

• Authors: Catherine Guevremont, Ahmed Alasker, Pierre I Karakiewicz
• Journal: Current opinion in supportive and palliative care (Curr Opin Support Palliat Care) Vol. 3 Issue 3 Pg. 170-9 (Sep 2009) ISSN: 1751-4266 [Electronic] United States
• PMID: 19528803 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Benzenesulfonates
• Indoles
• Phenylurea Compounds
• Pyridines
• Pyrroles
• Niacinamide
• temsirolimus
• Sorafenib
• Protein-Tyrosine Kinases
• Sunitinib
• Sirolimus

Topics

• Antineoplastic Agents (adverse effects, therapeutic use)
• Benzenesulfonates (adverse effects, therapeutic use)
• Carcinoma, Renal Cell (drug therapy, secondary)
• Clinical Trials as Topic
• Drug-Related Side Effects and Adverse Reactions (prevention & control, therapy)
• Humans
• Indoles (adverse effects, therapeutic use)
• Kidney Neoplasms (drug therapy, pathology)
• Niacinamide (analogs & derivatives)
• Phenylurea Compounds
• Practice Guidelines as Topic
• Protein-Tyrosine Kinases (adverse effects, therapeutic use)
• Pyridines (adverse effects, therapeutic use)
• Pyrroles (adverse effects, therapeutic use)
• Sirolimus (adverse effects, analogs & derivatives, therapeutic use)
• Sorafenib
• Sunitinib