Abstract | INTRODUCTION: METHODS: RESULTS: The luminal A subtype was the most common subtype in male breast cancer (83%, 35/42), which was followed by the luminal B subtype (17%, 7/42). Basal-like and HER2+/ER- subtypes were not identified in this group. All carcinomas expressed ER and 67% of them were PR+. High nuclear grades were more common in the luminal B subtype (71%, 5/7) than in the luminal A subtype (34%, 12/35). The luminal B subtype carcinomas expressed EGFR (42%, 3/7) and NF-kappaB (57%, 4/7) more frequently than the luminal A subtype did (17%, 6/35 and 37%, 13/35, respectively). CONCLUSIONS:
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Authors | Yimin Ge, Nour Sneige, Mahmoud A Eltorky, Zhiqin Wang, E Lin, Yun Gong, Ming Guo |
Journal | Breast cancer research : BCR
(Breast Cancer Res)
Vol. 11
Issue 3
Pg. R28
( 2009)
ISSN: 1465-542X [Electronic] England |
PMID | 19442295
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Keratin-5
- Keratin-6
- NF-kappa B
- ERBB2 protein, human
- ErbB Receptors
- Receptor, ErbB-2
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Topics |
- Aged
- Breast Neoplasms
(metabolism, pathology)
- Breast Neoplasms, Male
(classification, metabolism, pathology)
- ErbB Receptors
(biosynthesis)
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
(methods)
- In Situ Hybridization, Fluorescence
- Keratin-5
(biosynthesis)
- Keratin-6
(biosynthesis)
- Male
- Middle Aged
- NF-kappa B
(biosynthesis)
- Receptor, ErbB-2
(biosynthesis)
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