Immunohistochemical expression of interleukin-4, -6, -8, and -12 in inflammatory cells in surrounding invasive front of oral squamous cell carcinoma.

Abstract

BACKGROUND:

Cytokines play important roles in the diverse interactions between tumor microenvironment and malignant cells. This study evaluated the association of interleukin (IL)-4, -6, -8, and -12 expressions and clinicopathologic parameters of 35 primary oral squamous cell carcinomas (OSCCs).

METHODS:

Patients were staged according to the TNM clinical staging. Malignancy grading of invasive front was evaluated in hematoxylin-eosin (H&E)-stained slides. Immunohistochemical technique was performed on frozen tissue sections. Association between clinicopathologic parameters and IL expression were analyzed using nonparametric Kruskal-Wallis (alpha = 0.05) and Mann-Whitney U tests, with Bonferroni correction. Correlations between interleukins were analyzed by the Spearman coefficient.

RESULTS:

Expression of ILs was verified in all samples; however, this finding was not related to clinicopathologic parameters. It was not the observed correlation between ILs.

CONCLUSIONS:

Expression of IL-4, -6, -8, and -12 in the invasive front of OSCC is not involved with the clinicopathologic parameters of the disease.

• Authors: Marcos Vinícius Macedo de Oliveira, Carlos Alberto de Carvalho Fraga, Ricardo Santiago Gomez, Alfredo Maurício Batista D Paula
• Journal: Head & neck (Head Neck) Vol. 31 Issue 11 Pg. 1439-46 (Nov 2009) ISSN: 1097-0347 [Electronic] United States
• PMID: 19424975 (Publication Type: Journal Article)
• Copyright: (c) 2009 Wiley Periodicals, Inc. Head Neck, 2009.

Chemical References

• Interleukins

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (metabolism, pathology, surgery)
• Cohort Studies
• Female
• Frozen Sections
• Humans
• Inflammation (etiology, metabolism, pathology)
• Interleukins (metabolism)
• Leukocytes (metabolism)
• Male
• Middle Aged
• Mouth Neoplasms (metabolism, pathology, surgery)
• Neoplasm Invasiveness
• Neoplasm Staging
• Predictive Value of Tests
• Treatment Outcome
• Tumor Burden