The CALM and CALM/AF10 interactor CATS is a marker for proliferation.

Abstract

The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.

• Authors: Leticia Fröhlich Archangelo, Philipp A Greif, Michael Hölzel, Thomas Harasim, Elisabeth Kremmer, Gerhard K H Przemeck, Dirk Eick, Aniruddha Jayant Deshpande, Christian Buske, Martin Hrabé de Angelis, Sara Teresinha Olalla Saad, Stefan K Bohlander
• Journal: Molecular oncology (Mol Oncol) Vol. 2 Issue 4 Pg. 356-67 (Dec 2008) ISSN: 1878-0261 [Electronic] United States
• PMID: 19383357 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Carrier Proteins
• Intracellular Signaling Peptides and Proteins
• Monomeric Clathrin Assembly Proteins
• Neoplasm Proteins
• Nuclear Proteins
• Oncogene Proteins, Fusion
• PIMREG protein, human
• RNA, Neoplasm

Topics

• Animals
• Biomarkers, Tumor
• Carrier Proteins (analysis, genetics)
• Cell Cycle
• Cell Proliferation
• Cell Transformation, Neoplastic
• Embryonic Development (genetics)
• Genes, Essential (genetics)
• Hematopoietic Stem Cells (pathology)
• Humans
• Intracellular Signaling Peptides and Proteins
• Leukemia (etiology)
• Mice
• Monomeric Clathrin Assembly Proteins (analysis, genetics)
• Neoplasm Proteins (analysis, genetics)
• Nuclear Proteins
• Oncogene Proteins, Fusion
• RNA, Neoplasm (analysis)