Abstract | BACKGROUND: AIM: To assess the additional value of OGTT on top of fasting glucose levels in vascular surgery patients to predict long-term cardiovascular outcome. METHODS: RESULTS:
Impaired glucose tolerance (n = 104) and DM (n = 43) were detected by fasting glucose levels in 26 (25%) and 12 (28%) patients, and by OGTT in 78 (75%) and 31 (72%) patients, respectively. During follow-up, 131 patients experienced a cardiovascular event. With multivariable analysis, patients with IGT showed a significant increased risk for cardiovascular events (hazard ratio 2.77, 95% CI 1.83-4.20) and mortality (hazard ratio 2.06, 95% CI 1.03-4.12). Patients with DM showed a nonsignificant increased risk for cardiovascular events. CONCLUSION:
Vascular surgery patients with IGT or DM detected by preoperative OGTT have an increased risk of developing cardiovascular events and mortality during long-term follow-up. It is recommended that nondiabetic vascular surgery patients should be tested for glucose regulation disorders before surgery.
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Authors | Jan-Peter van Kuijk, Martin Dunkelgrun, Frodo Schreiner, Willem-Jan Flu, Wael Galal, Ron T van Domburg, Sanne E Hoeks, Yvette R B M van Gestel, Jeroen J Bax, Don Poldermans |
Journal | American heart journal
(Am Heart J)
Vol. 157
Issue 5
Pg. 919-25
(May 2009)
ISSN: 1097-6744 [Electronic] United States |
PMID | 19376322
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Blood Glucose
(metabolism)
- Diabetes Mellitus
(blood, diagnosis)
- Elective Surgical Procedures
(methods)
- Female
- Follow-Up Studies
- Glucose Tolerance Test
(methods)
- Heart Diseases
(blood, epidemiology)
- Humans
- Incidence
- Male
- Netherlands
(epidemiology)
- Preoperative Care
(methods)
- Prognosis
- Prospective Studies
- Risk Factors
- Survival Rate
- Time Factors
- Vascular Diseases
(blood, surgery)
- Vascular Surgical Procedures
(methods)
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