Abstract | PURPOSE: Low tidal volume ventilation and permissive hypercapnia are required in patients with sepsis complicated by ARDS. The effects of hypercapnia on tissue oxidative metabolism in this setting are unknown. We therefore determined the effects of moderate hypercapnia on markers of systemic and splanchnic oxidative metabolism in an animal model of endotoxemia. METHODS: Anesthetized rats maintained at a PaCO(2) of 30, 40 or 60 mmHg were challenged with endotoxin. A control group (PaCO(2) 40 mmHg) received isotonic saline. Hemodynamic variables, arterial lactate, pyruvate, and ketone bodies were measured at baseline and after 4 h. Tissue adenosine triphosphate ( ATP) and lactate were measured in the small intestine and the liver after 4 h. RESULTS: CONCLUSIONS: During endotoxemia in rats, moderate hypercapnia prevents the deterioration of tissue energetics in the intestine.
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Authors | Alex Gnaegi, François Feihl, Olivier Boulat, Bernard Waeber, Lucas Liaudet |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 35
Issue 7
Pg. 1297-304
(Jul 2009)
ISSN: 1432-1238 [Electronic] United States |
PMID | 19373455
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Carbon Dioxide
(administration & dosage, physiology)
- Endotoxemia
(physiopathology)
- Energy Metabolism
(drug effects, physiology)
- Hypercapnia
(metabolism)
- Oxygen Consumption
- Random Allocation
- Rats
- Rats, Wistar
- Respiration, Artificial
- Respiratory Distress Syndrome
(physiopathology, therapy)
- Sepsis
(physiopathology)
- Splanchnic Circulation
(drug effects, physiology)
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