Pathologic stage I and II Hodgkin's disease. Long-term results at three Connecticut hospitals.

Abstract

Three radiation therapy departments in Connecticut (Uncas on Thames Hospital, Norwich; Yale-New Haven Hospital, New Haven; and the Hospital of Saint Raphael, New Haven) have consistently used the strategy of staging laparotomy with splenectomy for clinical stage I and II Hodgkin's disease patients with primary radiation therapy as initial therapy for most pathologic stage (PS) I and II patients. From 1971 through 1986, 239 PS I and II patients were treated at these three institutions and 94% received radiation therapy alone as initial treatment. With a minimum follow-up time of one year and a maximum follow-up time of 18 years (mean: 7.3 years), only 19 (8%) of the 239 patients have ultimately died of Hodgkin's disease. Two factors were responsible for the low death rate due to Hodgkin's disease: 1) 176 patients (74%) went into complete remission following initial therapy and did not experience a relapse; and 2) 63 patients relapsed following initial therapy; however, subsequent salvage therapy was successful in 44 (70%) of these 63 patients. The overall 10-year and 18-year survival rates were 81% and 78%, respectively. Staging laparotomy with initial radiation therapy for most PS I and II patients remains an important and highly successful strategy for Hodgkin's disease.

• Authors: R E Peschel, D Hou-Wun Mai, S Dowling, A Knowlton, L Farber, J J Fischer
• Journal: Connecticut medicine (Conn Med) Vol. 55 Issue 8 Pg. 449-52 (Aug 1991) ISSN: 0010-6178 [Print] United States
• PMID: 1935066 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Child
• Combined Modality Therapy
• Connecticut
• Female
• Hodgkin Disease (pathology, therapy)
• Hospitals
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local
• Neoplasm Staging
• Retrospective Studies