[Chronic kidney disease (CKD) and bone. Pleiotropic actions of vitamin D and survival advantage].

Abstract

In addition to its actions on bone and mineral metabolism, vitamin D plays various roles in diverse systems. Vitamin D suppresses the renin-angiotensin system, increases insulin secretion and sensitivity, protects against cardiac hypertrophy, and increases left ventricular contraction. Also, vitamin D has anti-atherogenic and anti-inflammatory activities. Observational cohort studies in dialysis and predialysis patients with chronic renal failure show that vitamin D users, as compared to non-users, have better survival rate. Furthermore, the use of active vitamin D is associated with decreased proteinuria and a lower risk for developing end-stage renal disease. Further evidence is needed to establish these pleiotropic actions of vitamin D.

• Authors: Tetsuo Shoji, Yoshiki Nishizawa
• Journal: Clinical calcium (Clin Calcium) Vol. 19 Issue 4 Pg. 514-21 (Apr 2009) ISSN: 0917-5857 [Print] Japan
• PMID: 19329830 (Publication Type: Journal Article, Review)

Chemical References

• Insulin
• Minerals
• Vitamin D

Topics

• Animals
• Atherosclerosis (drug therapy)
• Bone and Bones (metabolism)
• Cardiomegaly (prevention & control)
• Depression, Chemical
• Heart Ventricles
• Humans
• Inflammation (drug therapy)
• Insulin (metabolism)
• Insulin Secretion
• Kidney Failure, Chronic (prevention & control)
• Minerals (metabolism)
• Myocardial Contraction (drug effects)
• Prognosis
• Proteinuria (prevention & control)
• Renal Dialysis (adverse effects, mortality)
• Renin-Angiotensin System (drug effects)
• Stimulation, Chemical
• Survival Rate
• Vitamin D (pharmacology, physiology, therapeutic use)