Abstract | INTRODUCTION: METHODS AND RESULTS: We retrospectively analysed the association between metabolic features and the incidence of new-onset POAF in a total of 2214 male patients <65 years who underwent first isolated CABG. Anthropometric data including waist circumference (WC) and complete preoperative lipid profile were available. We also conducted a nested case-control substudy including 147 patients who developed POAF, and were matched for age with a control population. In these patients, C-reactive protein, interleukin-6 (IL-6), and thiobarbituric acid-reactive substances ( TBARS; evaluating the oxidative stress) blood levels were determined. In the whole cohort, 19.6% of patients developed POAF. On univariate analysis, body mass index (BMI; P = 0.002) and WC (P = 0.001) were the only anthropometric variables significantly associated with increased incidence of POAF. In the multivariable logistic model, the only independent predictors of POAF were a WC > 102 cm [odds ratio (OR) = 1.40, P = 0.04)] and older age (OR = 1.08, P < 0.001). In the nested case-control substudy C-reactive protein, IL-6, and TBARS levels were not significantly different in patients with or without POAF. Of particular significance, patients with elevated WC > 102 cm and C-reactive protein > 1.5 mg/L or IL-6 >2.2 pg/mL were at a high risk of developing POAF (respectively, OR = 2.32, P = 0.02 and OR = 2.27, P = 0.03). CONCLUSION:
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Authors | Nicolas Girerd, Philippe Pibarot, Dominique Fournier, Pascal Daleau, Pierre Voisine, Gilles O'Hara, Jean-Pierre Després, Patrick Mathieu |
Journal | European heart journal
(Eur Heart J)
Vol. 30
Issue 10
Pg. 1270-8
(May 2009)
ISSN: 1522-9645 [Electronic] England |
PMID | 19329496
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Interleukin-6
- Thiobarbituric Acid Reactive Substances
- C-Reactive Protein
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Topics |
- Age Factors
- Atrial Fibrillation
(epidemiology, etiology)
- Biomarkers
(blood)
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Coronary Artery Bypass
- Epidemiologic Methods
- Humans
- Interleukin-6
(blood)
- Leukocyte Count
- Male
- Metabolic Syndrome
(complications, epidemiology)
- Middle Aged
- Obesity, Abdominal
(complications)
- Postoperative Complications
(epidemiology, etiology)
- Postoperative Period
- Smoking
(epidemiology)
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Treatment Outcome
- Waist Circumference
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