Abstract | BACKGROUND AND DESIGN: RESULTS: --Our study, based on a retrospective observation of 12 patients using 4% N-acetyl-4-S-cysteaminylphenol in oil-in-water emulsion, showed a complete loss (8%), a marked improvement (66%), or a moderate improvement (25%) of melasma lesions. Visible changes of melanoderma can be seen in 2 to 4 weeks after daily topical application. This depigmentation was associated with a decrease in the number of functioning melanocytes and in the number of melanosomes transferred to keratinocytes. N-acetyl-4-S-cysteaminylphenol is the tyrosinase substrate, and, on exposure to tyrosinase, it formed a melanin-like pigment. CONCLUSIONS:
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Authors | K Jimbow |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 127
Issue 10
Pg. 1528-34
(Oct 1991)
ISSN: 0003-987X [Print] United States |
PMID | 1929460
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antineoplastic Agents
- Cysteamine
- 4-S-cysteaminylphenol
|
Topics |
- Adult
- Antineoplastic Agents
(therapeutic use)
- Cysteamine
(analogs & derivatives, therapeutic use)
- Female
- Humans
- Male
- Melanosis
(complications, drug therapy, pathology)
- Microscopy, Electron
- Middle Aged
- Skin Pigmentation
(drug effects)
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