Abstract | OBJECTIVE: DESIGN AND PATIENTS: This was a prospective cohort study of incident dialysis patients starting HD or PD. Inflammation ( C-reactive protein >or=5 or >or=10 mg/L), malnutrition (1 to 5 on the 7-point subjective global assessment [SGA]), and low protein intake (normalized protein equivalent of nitrogen appearance [nPNA] <0.99 g/kg/day) were measured at 3 months after the start of dialysis. SETTING: The study involved 38 dialysis centers in The Netherlands. MAIN OUTCOME MEASURE: We ascertained all-cause mortality during the first 2 years after the start of dialysis. RESULTS: In total, 700 patients were included (mean SD age, 59 [+/-15] years; serum albumin, 3.3 (0.7) g/dL; 60% men; 454 starting HD, and 246 starting PD). The 2-year mortality was 21%. In HD patients, the mortality (hazard ratio [HR], with 95% confidence interval [95% CI]) per unit decrease in serum albumin (g/dL) was 1.47 (95% CI, 1.07 to 2.00). Adjustment for SGA did not decrease this risk, whereas adjustment for nPNA decreased the HR to 1.45 (95% CI, 1.06 to 1.97). The mortality risk decreased to 1.30 (95% CI, 0.95 to 1.78) after adjustment for inflammation, and did not further decrease after additional adjustment for SGA and nPNA. Additional adjustments for age, sex, and comorbidity decreased the HR to 1.09 (95% CI, 0.79 to 1.51). In PD patients, the effects of adjustments on the mortality risk of serum albumin (1.38; 95% CI, 0.87 to 2.20) were similar. CONCLUSION: In dialysis patients, a 1-g/dL decrease in serum albumin was associated with an increased mortality risk of 47% in HD patients and 38% in PD patients. These mortality risks were in part explained by the inflammatory pathway. The mortality risks associated with serum albumin were not a consequence of malnutrition, as measured with SGA and nPNA. These findings imply that nutritional status cannot be assessed with precision by the measurement of serum albumin in dialysis patients.
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Authors | Renée de Mutsert, Diana C Grootendorst, Fleur Indemans, Elisabeth W Boeschoten, Raymond T Krediet, Friedo W Dekker, Netherlands Cooperative Study on the Adequacy of Dialysis-II Study Group |
Journal | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
(J Ren Nutr)
Vol. 19
Issue 2
Pg. 127-35
(Mar 2009)
ISSN: 1532-8503 [Electronic] United States |
PMID | 19218039
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Dietary Proteins
- Serum Albumin
- C-Reactive Protein
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Topics |
- Biomarkers
(blood)
- C-Reactive Protein
(analysis, metabolism)
- Cause of Death
- Cohort Studies
- Dietary Proteins
(administration & dosage)
- Female
- Humans
- Inflammation
(blood, etiology, mortality)
- Kidney Failure, Chronic
(blood, mortality, therapy)
- Male
- Malnutrition
(blood, mortality)
- Middle Aged
- Nutrition Assessment
- Nutritional Status
- Peritoneal Dialysis
(mortality)
- Prospective Studies
- Renal Dialysis
(mortality)
- Risk Factors
- Serum Albumin
(analysis, metabolism)
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