[Investigation on inhibition of HIV III B virus with extractions of Juglans regia].

Abstract

OBJECTIVE:

To study the effect of anti-HIV III B virus with extractions from Juglans regia, so as to searching for the new and efficacious leading compound of AIDS therapy.

METHOD:

Phytochemical and chromatographical techniques were used to isolate compounds from J. regia; MT4 cells and HIV III B virus were used to study the effect of anti-HIV activity in vitro. BIACORE 3000 molecule coupled equipment were used for the target research also.

RESULT:

Two extractions (B&E) were isolated from J. regia which possess the effect of anti-HIV activity. Targets study found that extraction B could affected on HIV-1 gp-41 fusing protein and extraction E could affected on HIV-1 integrase respectively.

CONCLUSION:

J. regia is a traditional Chinese medicine with active anti-HIV activity and worth to be studied further.

• Authors: Zhao-Mei Liu, Rui-Xing Wen, Hong-Tao Ma, Yi-Shu Yang, Xiao-Li Wang, Xiu-Hua Lv, Ze-Lin Li
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 33 Issue 21 Pg. 2535-8 (Nov 2008) ISSN: 1001-5302 [Print] China
• PMID: 19149267 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Plant Extracts

Topics

• Cell Line
• Drugs, Chinese Herbal (chemistry, pharmacology)
• HIV-1 (drug effects)
• Humans
• Juglans (chemistry)
• Plant Extracts (chemistry, pharmacology)