Abstract | BACKGROUND: OBJECTIVES: Given the ability of atrazine to exert estrogen-like activity in cancer cells, we evaluated the potential of atrazine to signal through GPR30 in stimulating biological responses in cancer cells. METHODS AND RESULTS: CONCLUSIONS: Our results indicate a novel mechanism through which atrazine may exert relevant biological effects in cancer cells. On the basis of the present data, atrazine should be included among the environmental contaminants potentially able to signal via GPR30 in eliciting estrogenic action.
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Authors | Lidia Albanito, Rosamaria Lappano, Antonio Madeo, Adele Chimento, Eric R Prossnitz, Anna Rita Cappello, Vincenza Dolce, Sergio Abonante, Vincenzo Pezzi, Marcello Maggiolini |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 116
Issue 12
Pg. 1648-55
(Dec 2008)
ISSN: 0091-6765 [Print] United States |
PMID | 19079715
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Retracted Publication)
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Chemical References |
- DNA Primers
- Herbicides
- Receptors, Estrogen
- Receptors, G-Protein-Coupled
- Aromatase
- Extracellular Signal-Regulated MAP Kinases
- Atrazine
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Topics |
- Aromatase
(metabolism)
- Atrazine
(toxicity)
- Base Sequence
- Cell Proliferation
(drug effects)
- DNA Primers
- Enzyme Activation
- Extracellular Signal-Regulated MAP Kinases
(metabolism)
- Female
- Herbicides
(toxicity)
- Humans
- Ovarian Neoplasms
(pathology, physiopathology)
- Phosphorylation
- Receptors, Estrogen
(physiology)
- Receptors, G-Protein-Coupled
(physiology)
- Tumor Cells, Cultured
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