Abstract | BACKGROUND: Early clinical trials of HER2/neu-derived peptide vaccines indicate that they may be useful for preventing recurrence in breast cancer patients rendered disease-free after standard-of-care therapy. An effective vaccination strategy will probably require stimulation of T helper (Th) cells. AE37 is an HER2/neu-derived peptide that has been modified to enhance antigen-specific stimulation of Th cells by linkage of the Ii-Key moiety of the MHC class II-associated invariant chain (Ii protein). OBJECTIVE: To review the literature regarding the role of a Th response in immunotherapy with a focus on this novel HER2/neu-derived AE37 peptide. RESULTS/CONCLUSION: Improved immuno-genicity of the AE37 Ii-key hybrid peptide has been demonstrated in animal models, ex vivo patient cells, and, most recently, in a Phase I clinical trial in breast cancer patients. Future clinical trials incorporating AE37 into a peptide vaccine strategy are warranted.
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Authors | Elizabeth A Mittendorf, Jarrod P Holmes, James L Murray, Eric von Hofe, George E Peoples |
Journal | Expert opinion on biological therapy
(Expert Opin Biol Ther)
Vol. 9
Issue 1
Pg. 71-8
(Jan 2009)
ISSN: 1744-7682 [Electronic] England |
PMID | 19063694
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- AE37 vaccine
- Antigens, Differentiation, B-Lymphocyte
- Cancer Vaccines
- Histocompatibility Antigens Class II
- invariant chain
- Granulocyte-Macrophage Colony-Stimulating Factor
- Receptor, ErbB-2
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Topics |
- Animals
- Antigens, Differentiation, B-Lymphocyte
(immunology)
- CD4-Positive T-Lymphocytes
(immunology)
- Cancer Vaccines
(adverse effects, immunology)
- Clinical Trials, Phase I as Topic
- Granulocyte-Macrophage Colony-Stimulating Factor
(pharmacology)
- Histocompatibility Antigens Class II
(immunology)
- Humans
- Neoplasms
(immunology)
- Receptor, ErbB-2
(immunology)
- Vaccination
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