GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function.

Abstract	Steroid receptor coactivators (SRCs) exert profound effects on animal development and physiology. Genetic ablation experiments indicate that various SRC proteins might have differential physiological roles; however, clear evidence of functional specificity has not yet been shown at the molecular level. Here we report the identification of a new SRC1 interacting protein, glutamate-rich coactivator interacting with SRC1 (GAS), which contains a central glutamate-rich region and has transactivation activity. Interestingly, GAS interacts only with SRC1, and not with glucocorticoid receptor interacting protein 1 (GRIP1) or amplified in breast cancer 1 (AIB1), the other two members of the SRC family. It interacts with oestrogen receptor-alpha (ERalpha) and participates in both oestrogen receptor-regulated gene transcription and oestrogen-stimulated G1/S cell-cycle transition. Our data thus indicate that GAS is a new transcription cofactor and that different SRCs are associated with distinct secondary cofactors.
Authors	Jing Liang, Hua Zhang, Yu Zhang, Ying Zhang, Yongfeng Shang
Journal	EMBO reports (EMBO Rep) Vol. 10 Issue 1 Pg. 51-7 (Jan 2009) ISSN: 1469-3178 [Electronic] England
PMID	19039327 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Carrier Proteins Cell Cycle Proteins DNA-Binding Proteins Estrogen Receptor alpha Nuclear Proteins PAGR1 protein, human Receptors, Steroid Glutamic Acid
Topics	Amino Acid Sequence Animals Carrier Proteins (chemistry, genetics, metabolism) Cell Cycle Proteins Cell Line Cloning, Molecular DNA-Binding Proteins Estrogen Receptor alpha (metabolism) Glutamic Acid (metabolism) Humans Molecular Sequence Data Nuclear Proteins Organ Specificity Protein Binding Receptors, Steroid (metabolism) Sequence Alignment Sequence Homology, Amino Acid Transcriptional Activation (genetics)

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