[Strontium-89: a desirable therapeutic for bone metastases of prostate cancer].

Abstract

OBJECTIVE:

To evaluate the efficacy of strontium-89 (89Sr) in the treatment of painful bone metastases of prostate cancer.

METHODS:

A total of 116 patients with painful bone metastases of prostate cancer received bilateral orchiectomy and incretion, followed by intravenous injection of 89Sr at the dose of 1.48-2.22 MBq (40-60 microCi)/kg. The clinical effects were evaluated by follow-up analysis.

RESULTS:

After the 89Sr treatment, appetite and sleep were evidently improved in 33.6% and 56.0% of the patients respectively, the applied dose of anodyne reduced in 61.2%, pain alleviated in 83.6%, with an absolute palliation rate of 24.1%. Pain relief started at 3-21 (10.2 +/- 6.5) days and lasted 3-12 (5.3 +/- 2.2) months. Flare ache occurred in 31.9% of the patients. Compared with pre-treatment, the mean score on Karnofsky's performance status (KPS) was 20.0% higher, and the WBC count decreased to 3.0-3.9 x 10(6)/L in 18.1% of the patients. Whole body bone scintigraphy of 53 followed-up patients showed that 39 (73.6%) of them exhibited an obvious decrease in the number of metastases, 10 (18.9% remained in a stabilized state and only 4 (7.5% deteriorated.

CONCLUSION:

89Sr, capable of inhibiting bone metastasis, palliating pain and improving the quality of life with few adverse effects, can be used as a desirable therapeutic for painful bone metastases of prostate cancer.

• Authors: Yu-Bo Ma, Wei-Li Yan, Ji-Can Dai, Feng Xu, Qi Yuan, He-Hai Shi
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 14 Issue 9 Pg. 819-22 (Sep 2008) ISSN: 1009-3591 [Print] China
• PMID: 18998467 (Publication Type: English Abstract, Journal Article)

Chemical References

• Strontium Radioisotopes

Topics

• Aged
• Aged, 80 and over
• Bone Neoplasms (radiotherapy, secondary)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Pain, Intractable (radiotherapy)
• Prostatic Neoplasms (pathology)
• Strontium Radioisotopes (therapeutic use)
• Treatment Outcome