Abstract |
In developing new insulin-mimetic zinc(II) complexes with various ligands including a biodegradable polymer, we prepared and characterized a Zn( gamma-pga) complex in solution as well as in solid, and investigated its in vitro insulin-mimetic activity and in vivo antidiabetic effect in type-2 diabetic KKA(y) mice. The in vitro insulin-mimetic activity of the Zn( gamma-pga) complex was considerable better than that of ZnSO(4). The Zn( gamma-pga) complex normalized the hyperglycemia in KKA(y) mice within 21 d when administrated orally at doses of 10-20 mg (0.15-0.31 mmol) Zn per kg body mass for 30 d. In addition, the impaired glucose tolerance, elevated HbA(1c) levels and metabolic syndromes were significantly improved in Zn( gamma-pga)-treated KKA(y) mice relative to those administrated with saline and ZnSO(4).
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Authors | Subarna Karmaker, Tapan K Saha, Yutaka Yoshikawa, Hiromu Sakurai |
Journal | Macromolecular bioscience
(Macromol Biosci)
Vol. 9
Issue 3
Pg. 279-86
(Mar 10 2009)
ISSN: 1616-5195 [Electronic] Germany |
PMID | 18989849
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Insulin
- poly(gamma-glutamic acid)
- Polyglutamic Acid
- Zinc
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Topics |
- Administration, Oral
- Animals
- Diabetes Mellitus, Type 2
(drug therapy)
- Hyperglycemia
(drug therapy)
- Insulin
- Mice
- Mice, Inbred Strains
- Molecular Mimicry
- Polyglutamic Acid
(administration & dosage, analogs & derivatives, therapeutic use)
- Treatment Outcome
- Zinc
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