Association between glycoconjugate antibodies and Campylobacter infection in patients with Guillain-Barré syndrome.
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| Abstract |
In a retrospective study, we have analysed sera from a well-characterised Guillain-Barré syndrome (GBS) patient group for antibodies that react with gangliosides. Of 95 GBS patients and 85 control patients analysed, we found that 14 (15%) of GBS patients but only one control patient had antibodies that react with the gangliosides GM1 and/or GD1b but not GM2, GD1a and GT1b using a sensitive enzyme-linked immunosorbent assay (ELISA). This pattern of reactivity suggests binding to the carbohydrate structure Gal(beta 1-3)GalNAc which is shared between some glycolipids and glycoproteins. Similar antibodies have been found previously in a subpopulation of patients with lower motor neuron disease. In the present study, the predominant immunoglobulin class of these anti-glycoconjugate antibodies was IgG rather than IgM. A correlation was found between the presence of these antibodies and prognosis in terms of disability at 3 and 12 months after presentation. Patients with anti-glycoconjugate antibodies also had a higher incidence of previous Campylobacter infections than the rest of the patient group, although the significance of this remains to be determined.
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| Authors | F S Walsh, M Cronin, S Koblar, P Doherty, J Winer, A Leon, R A Hughes |
| Journal | Journal of neuroimmunology (J Neuroimmunol) Vol. 34 Issue 1 Pg. 43-51 (Oct 1991) ISSN: 0165-5728 [Print] Netherlands |
| PMID | 1894733 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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