Recent and emerging anti-diabetes targets.

Abstract

Diabetes is a disease that affects over 150 million people worldwide for which there are multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, diabetes rates in both developed and developing countries are increasing at an alarming rate. Current medications are not adequately effective in maintaining long-term glycemic control in most patients, even when used in combination, leaving diabetics susceptible to developing life threatening and debilitating complications such as cardiovascular disease, blindness, kidney complications, and amputations. Consequently, there is a critical need for more potent pharmacotherapies with novel mechanisms of action. A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed.

• Authors: Michael L Mohler, Yali He, Zhongzhi Wu, Dong Jin Hwang, Duane D Miller
• Journal: Medicinal research reviews (Med Res Rev) Vol. 29 Issue 1 Pg. 125-95 (Jan 2009) ISSN: 1098-1128 [Electronic] United States
• PMID: 18855890 (Publication Type: Journal Article, Review)
• Copyright: (c) 2008 Wiley Periodicals, Inc.

Chemical References

• Hypoglycemic Agents

Topics

• Animals
• Diabetes Mellitus (drug therapy, metabolism)
• Humans
• Hypoglycemic Agents (chemistry, classification, pharmacology, therapeutic use)