Recent studies suggested a role of appetite regulating
peptides like
leptin and
ghrelin in
alcohol dependence and particularly in the neurobiology of alcohol craving. Aim of the present study was to investigate alterations of the
adipocytokines adiponectin and
resistin in alcohol-dependent patients. We analyzed a sample of 88 patients at admission for alcohol detoxification and after 1 week of withdrawal treatment in comparison to 89 healthy controls.
Adiponectin and
resistin serum levels were measured using commercial ELISA kits. The extent of alcohol craving was obtained using the Obsessive Compulsive Drinking Scale (OCDS).
Adiponectin and
resistin serum levels were significantly elevated in patients with
alcohol dependence at both dates (admission and after 1 week of treatment) compared to healthy controls.
Adiponectin decreased significantly during the course of withdrawal (T=3.44, p=0.001) while
resistin serum levels showed a slight increase (T=-1.83, p=0.071). In a multivariate approach the extent of alcohol craving was significantly associated with
adiponectin but not with
resistin serum levels in male patients (Beta=-0.255, p=0.025). Results for female patients were not significant. Our findings provide first evidence for an alteration of the
adipocytokines adiponectin and
resistin during alcohol withdrawal. Furthermore,
adiponectin may be involved in the neurobiology of alcohol craving, possibly via its effects on the hypothalamic circuits.