Asthma management by monitoring sputum neutrophil count.

Abstract	We report the utility of quantitative cell counts in sputum in monitoring therapy of a patient with poorly controlled asthma. Recurrent neutrophilic bronchitis without an eosinophilic bronchitis led to the identification of Chlamydophila pneumoniae as the cause of bronchitis and asthma exacerbation. Serial examination of blood and sputum by polymerase chain reaction for C pneumoniae helped to prevent exacerbations by prophylactic antibiotic therapy, reduce the dose of prednisone and inhaled corticosteroids, and improve asthma control.
Authors	Shelley Pallan, James B Mahony, Paul M O'Byrne, Parameswaran Nair
Journal	Chest (Chest) Vol. 134 Issue 3 Pg. 628-630 (Sep 2008) ISSN: 0012-3692 [Print] United States
PMID	18779198 (Publication Type: Case Reports, Journal Article)
Chemical References	Adrenal Cortex Hormones Anti-Bacterial Agents Anti-Infective Agents
Topics	Adrenal Cortex Hormones (therapeutic use) Anti-Bacterial Agents (therapeutic use) Anti-Infective Agents (therapeutic use) Asthma (drug therapy, microbiology, pathology) Bronchitis (diagnosis, pathology) Chlamydophila Infections (complications, diagnosis, drug therapy) Chlamydophila pneumoniae Female Humans Lung (microbiology, pathology) Middle Aged Neutrophils (pathology) Recurrence Sputum (cytology)

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