Abstract | BACKGROUND:
Brain stem tumors (BST) constitute 20% of all intracranial tumors. Survival for these patients has been very poor worldwide. Four different treatment schemes have been evaluated at our institution, with only a discrete increment in survival when treated with carboplatin- vincristine and fluvastatin (CVF). Low-dose, continuous antiangiogenic treatment has been recently introduced in the treatment of cancer. Our objective was to determine tumor response to metronomic chemotherapy combined with an antiangiogenic drug and fluvastatin and to calculate the survival of pediatric patients with brain stem tumors. METHODS: This was a phase II study. A magnetic resonance (MRI) study was made at inclusion and after the fourth course. Routine laboratory analyses were performed prior to each treatment scheme. Patients received four courses of chemotherapy every 28 days consisting of thalidomide alternating with fluvastatin every 14 days and combined with carboplatin and vincristine every 14 days followed by radiotherapy (56 cGy) and four more courses of the same chemotherapy. Toxicity was evaluated according to Miller criteria. RESULTS: CONCLUSIONS:
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Authors | Enrique López-Aguilar, Ana Carolina Sepúlveda-Vildósola, Yadira Betanzos-Cabrera, Yael Guadalupe Rocha-Moreno, Graciela Gascón-Lastiri, Hugo Rivera-Márquez, Volkmar Wanzke-del-Angel, Fernando Cerecedo-Díaz, Hermilo de la Cruz-Yañez |
Journal | Archives of medical research
(Arch Med Res)
Vol. 39
Issue 7
Pg. 655-62
(Oct 2008)
ISSN: 0188-4409 [Print] United States |
PMID | 18760193
(Publication Type: Clinical Trial, Phase II, Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- Fatty Acids, Monounsaturated
- Indoles
- Fluvastatin
- Thalidomide
- Vincristine
- Carboplatin
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Topics |
- Angiogenesis Inhibitors
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Brain Stem Neoplasms
(drug therapy, mortality, radiotherapy)
- Carboplatin
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Fatty Acids, Monounsaturated
(administration & dosage, therapeutic use)
- Female
- Fluvastatin
- Humans
- Indoles
(administration & dosage, therapeutic use)
- Infant
- Magnetic Resonance Imaging
- Male
- Quality of Life
- Survival Rate
- Thalidomide
(administration & dosage, therapeutic use)
- Vincristine
(administration & dosage, therapeutic use)
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