Abstract | AIM: METHODS: RESULTS: Reliability of the measures was extremely high (intraclass correlations for the six measures all = 0.98). Within each instrument, there were no significant differences or outliers among the scores from the 10 investigators. Test/retest reliability was high for each measure: range = 0.77 to 0.95. The scores of the five acute activity measures correlated extremely well with one another. CONCLUSIONS: Currently available tools for measuring disease extent and activity in ANCA-associated vasculitis are highly correlated and reliable. These results provide investigators with confidence to compare different clinical trial data and helps form common ground as international research groups develop new, improved and universally accepted vasculitis disease assessment instruments.
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Authors | P A Merkel, D D Cuthbertson, B Hellmich, G S Hoffman, D R W Jayne, C G M Kallenberg, J P Krischer, R Luqmani, A D Mahr, E L Matteson, U Specks, J H Stone, Vasculitis Clinical Research Consortium |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 68
Issue 1
Pg. 103-6
(Jan 2009)
ISSN: 1468-2060 [Electronic] England |
PMID | 18664546
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
- Autoantibodies
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Topics |
- Acute Disease
- Antibodies, Antineutrophil Cytoplasmic
(immunology)
- Autoantibodies
(blood)
- Europe
- Humans
- Linear Models
- Observer Variation
- Random Allocation
- Sensitivity and Specificity
- Severity of Illness Index
- United States
- Vasculitis
(immunology)
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