MicroRNAs: key players in carcinogenesis and novel therapeutic targets.

Abstract

MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype. The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide.

• Authors: A H F Mirnezami, K Pickard, L Zhang, J N Primrose, G Packham
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 35 Issue 4 Pg. 339-47 (Apr 2009) ISSN: 1532-2157 [Electronic] England
• PMID: 18644693 (Publication Type: Journal Article, Review)

Chemical References

• MicroRNAs

Topics

• Apoptosis (genetics)
• Breast Neoplasms (genetics, therapy)
• Cell Differentiation (genetics)
• Colorectal Neoplasms (genetics, therapy)
• Female
• Gene Expression Profiling
• Genetic Therapy
• Humans
• Lung Neoplasms (genetics, therapy)
• Male
• MicroRNAs (analysis, classification, drug effects)
• Neoplasms (genetics, therapy)
• Prognosis
• Prostatic Neoplasms (genetics, therapy)
• Terminology as Topic