Successful use of the anti-CD25 antibody daclizumab in an adult patient with hemophagocytic lymphohistiocytosis.

Abstract	Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe inflammatory disorder marked by abnormal cytotoxic T and natural killer cell activity, resulting in impaired clearance of pathogen, excessive cytokine production, and continued immune system activation. Soluble IL-2 receptor (sIL-2R or sCD25) is typically elevated in HLH and can serve as a marker of disease activity, although its role in the pathophysiology of the disease is unclear. Here we present a case of an adult patient with steroid-dependent HLH who was treated successfully with daclizumab, a monoclonal anti-CD25 antibody, allowing successful withdrawal of steroid therapy without an increase in symptoms.
Authors	Rebecca L Olin, Kim E Nichols, Mojdeh Naghashpour, Mariusz Wasik, Brenda Shelly, Edward A Stadtmauer, Dan T Vogl
Journal	American journal of hematology (Am J Hematol) Vol. 83 Issue 9 Pg. 747-9 (Sep 2008) ISSN: 1096-8652 [Electronic] United States
PMID	18615554 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright 2008 Wiley-Liss, Inc.
Chemical References	Adrenal Cortex Hormones Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Biomarkers Immunoglobulin G Immunosuppressive Agents Interleukin-2 Receptor alpha Subunit Vincristine Doxorubicin Cyclosporine Cyclophosphamide Ferritins Daclizumab Prednisone
Topics	Adrenal Cortex Hormones (therapeutic use) Antibodies, Monoclonal (therapeutic use) Antibodies, Monoclonal, Humanized Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use) Biomarkers Cyclophosphamide (administration & dosage) Cyclosporine (therapeutic use) Daclizumab Doxorubicin (administration & dosage) Ferritins (blood) Humans Immunoglobulin G (therapeutic use) Immunosuppressive Agents (therapeutic use) Interleukin-2 Receptor alpha Subunit (antagonists & inhibitors, immunology) Killer Cells, Natural (immunology) Lymphohistiocytosis, Hemophagocytic (complications, drug therapy) Lymphoma, Large-Cell, Anaplastic (complications, drug therapy) Male Middle Aged Prednisone (administration & dosage) Recurrence T-Lymphocyte Subsets (chemistry, immunology) Vincristine (administration & dosage)

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