H+,K-ATPase antibodies in autoimmune gastritis: observations on the development of pernicious anemia.

Abstract

The prevalence and development of antibodies to H+,K+-ATPase were investigated with a sensitive enzyme-linked immunosorbent assay in 86 patients with autoimmune atrophic gastritis (type A). Sixty-nine of the patients had pernicious anemia, and 17 had simple atrophic gastritis. Elevated titers were found in 93% of pernicious anemia probands. Women had higher levels than men: 3.24 versus 1.58 U/l (p = 0.002) (upper reference limit, 0.55 U/l). The antibody levels did not change over 1-4 years, but a gradual decrease in titers over decades was observed. All patients with pernicious anemia had low levels of pepsinogen A, a product of the gastric chief and mucous neck cells (median, 8.5 micrograms/l; reference range, 10-90 percentile, 64.4-195.5 micrograms/l), and elevated serum gastrin values (greater than 55 pmol/l) were found in 87%. Serum pepsinogen A, but not serum gastrin, correlated with H+,K(+)-ATPase antibody titers (r = 0.35, p = 0.01). In the 17 cases with simple atrophic gastritis, H+,K(+)-ATPase antibodies correlated inversely with fundic mucosal gland destruction. The data indicate that H+,K(+)-ATPase antibody titers reflect the immune responsiveness of a given patient as well as the antigenic amount, dependent on the degree of mucosal destruction and the duration of the disease.

• Authors: P Burman, F A Karlsson, L Lööf, C K Axelsson, P B Szesci, K Borch
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 26 Issue 2 Pg. 207-14 (Feb 1991) ISSN: 0036-5521 [Print] England
• PMID: 1849312 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Pepsinogens
• Proton-Translocating ATPases
• Sodium-Potassium-Exchanging ATPase

Topics

• Adult
• Aged
• Anemia, Pernicious (blood, etiology, immunology, pathology)
• Antibodies (analysis)
• Atrophy
• Autoimmune Diseases (complications, immunology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Gastric Mucosa (pathology)
• Gastritis (blood, complications, immunology, pathology)
• Humans
• Male
• Middle Aged
• Pepsinogens (blood)
• Proton-Translocating ATPases (immunology)
• Sodium-Potassium-Exchanging ATPase (immunology)