[Combination of thiotropium bromide with almitrine and pulmonary rehabilitation in the treatment of patients with chronic obstructive pulmonary disease].

Abstract

AIM:

To elucidate efficacy of a combination almitrine+thiotropium bromide (TB)+pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) of stage II-III complicated with chronic respiratory failure (CRF).

MATERIAL AND METHODS:

Efficacy of therapy was compared in two groups of patients: group 1 (n = 22) received TB in a dose 18 mcg/day for one year, almitrine in a dose 10 mg/kg/day for 3 months, an 8 week course of PR, group 2 (n = 17) received TB and PR. The treatment efficacy was determined by spirometric parameters of external respiration function, blood gases, dyspnea indices, exercise tolerance assessed by 6-min walk test, quality of life (St. George Hospital Respiratory Questionnaire).

RESULTS:

Group 1 patients walked longer distance after a course of PR and 1 year later (by 90.5 +/- 25.4 and 44.5 +/- 10.2 m, respectively, p < 0.05), had reduced desaturation measured by pulsoxym-etry at the end of 6-min walk test, increased PaO2 in baseline under 70 mmHg (by 5.8 +/- 1.2 mmHg, p > 0.05), decreased exacerbation rate per 1 patient a year (by 25%).

CONCLUSION:

Combination treatment with TB, almitrine and PR is indicated for COPD patients with moderate hypoxemia.

• Authors: O N Titova, V A Ignat'ev, M D Didur, M Iu Kameneva, O A Sukhovskaia
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 80 Issue 3 Pg. 28-33 ( 2008) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 18441680 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Bronchodilator Agents
• Scopolamine Derivatives
• Almitrine
• Tiotropium Bromide

Topics

• Administration, Inhalation
• Almitrine (administration & dosage)
• Bronchodilator Agents (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Exercise Therapy (methods)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Pulmonary Disease, Chronic Obstructive (drug therapy, rehabilitation)
• Quality of Life
• Scopolamine Derivatives (administration & dosage)
• Tiotropium Bromide
• Treatment Outcome