Amelioration of experimental autoimmune encephalomyelitis by BLyS autovaccine.

Abstract	The B-lymphocyte stimulator (BLyS) is implicated in various pathophysiological processes. The overexpression of BLyS has been observed in some human diseases, including systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, and multiple sclerosis. This feature suggests that BLyS may be a therapeutic target for some human autoimmune diseases. We developed a therapeutic vaccine by coupling a tetanus toxoid T-helper cell epitope with the C-terminal of BLyS (TT-BLyS). This vaccine can induce high titers of neutralizing antibodies against BLyS in an animal model; the antibody has markedly protective effects on experimental autoimmune encephalomyelitis in rats, which is induced by inoculation of spinal cord homogenate. Our data suggest that the BLyS autovaccine may be a useful candidate for the treatment of some autoimmune diseases associated with the production of BLyS.
Authors	Xiaochang Xue, Guodong Feng, Meng Li, Xin Qin, Shouzhen Wu, Cun Zhang, Yanjie You, Weihua Wang, Changli Jiang, Yan Liu, Wenhua Zhu, Yonggang Ran, Zhen Zhang, Zhen Yan, Wei Han, Yingqi Zhang
Journal	Vaccine (Vaccine) Vol. 26 Issue 23 Pg. 2873-81 (Jun 02 2008) ISSN: 0264-410X [Print] Netherlands
PMID	18440104 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Autoantibodies Autoantigens B-Cell Activating Factor Vaccines Vaccines, Synthetic Immunoglobulin E Glyceraldehyde-3-Phosphate Dehydrogenases
Topics	Animals Autoantibodies (analysis, biosynthesis, genetics) Autoantigens (genetics, immunology, therapeutic use) B-Cell Activating Factor (biosynthesis, genetics, immunology) Behavior, Animal Cerebellum (pathology) Encephalomyelitis, Autoimmune, Experimental (immunology, prevention & control, psychology) Female Glyceraldehyde-3-Phosphate Dehydrogenases (metabolism) Humans Immunoglobulin E (analysis, biosynthesis) Immunohistochemistry Mice Mice, Inbred BALB C Motor Activity (physiology) Neutralization Tests Rabbits Rats Rats, Sprague-Dawley Spinal Cord (pathology) Vaccines (genetics, immunology, therapeutic use) Vaccines, Synthetic (genetics, immunology, therapeutic use)

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