The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes.

Abstract

We determined the IL-6 -174 G>C single nucleotide polymorphism, IL-6 mRNA expression in subcutaneous adipose tissue (SAT) and IL-6 plasma levels in HIV-1-infected patients with and without lipodystrophy and uninfected controls. HIV-1-infected patients had a greater prevalence of the IL-6 -174 C/C genotype and the C allele, higher SAT IL-6 mRNA expression and plasma IL-6 levels than controls. The IL-6 -174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy.

• Authors: Maria Saumoy, Miguel López-Dupla, Sergi Veloso, Carlos Alonso-Villaverde, Pere Domingo, Montserrat Broch, Merce Miranda, Blai Coll, Amadeu Saurí, Joan Vendrell, Cristóbal Richart, Francesc Vidal
• Journal: AIDS (London, England) (AIDS) Vol. 22 Issue 7 Pg. 893-6 (Apr 23 2008) ISSN: 1473-5571 [Electronic] England
• PMID: 18427208 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents
• Interleukin-6
• RNA, Messenger

Topics

• Adult
• Alleles
• Anti-HIV Agents (therapeutic use)
• Antiretroviral Therapy, Highly Active
• Case-Control Studies
• Cross-Sectional Studies
• Female
• Gene Frequency
• Genotype
• HIV Infections (drug therapy, immunology)
• HIV-1
• HIV-Associated Lipodystrophy Syndrome (drug therapy, immunology)
• Humans
• Interleukin-6 (blood, genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• RNA, Messenger (analysis)
• Subcutaneous Fat (immunology)