Abstract | OBJECTIVE: To prepare long-circulating liposome (LCL) for sustained release of nolatrexed dihydrochloride and evaluate the effect of this preparation against the growth of hepatocarcinoma cells in mice. METHODS: RESULTS: The mean diameter of the long-circulating nolatrexed dihydrochloride liposomes was 109 nm, with an entrapment efficiency of 68.5%. In vivo antitumor experiment showed that both the common liposomal and LCL preparations of nolatrexed dihydrochloride produced antitumor effect in vivo, and the latter had weaker antitumor effect than free and common liposomal preparation of nolatrexed dihydrochloride, but in the long term, the LCL preparation showed stronger antitumor effect with a tumor weight inhibition rate of 41.68%. CONCLUSION: LCL allows sustained release of nolatrexed dihydrochloride in vivo, and may effectively lengthen the relatively short half life of this drug after administration.
|
Authors | Si-ze Chen, Sen-ming Wang, Ji-ren Zhang |
Journal | Nan fang yi ke da xue xue bao = Journal of Southern Medical University
(Nan Fang Yi Ke Da Xue Xue Bao)
Vol. 28
Issue 3
Pg. 403-5
(Mar 2008)
ISSN: 1673-4254 [Print] China |
PMID | 18359701
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antineoplastic Agents
- Delayed-Action Preparations
- Drug Carriers
- Liposomes
- Quinazolines
- nolatrexed
|
Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, chemistry, therapeutic use)
- Delayed-Action Preparations
(administration & dosage, chemistry, therapeutic use)
- Drug Carriers
- Drug Compounding
(methods)
- Liposomes
(chemistry)
- Liver Neoplasms, Experimental
(drug therapy)
- Mice
- Quinazolines
(administration & dosage, chemistry, therapeutic use)
|