A hundred and thirty patients, including 60 patients with
psoriasis concurrent with chronic
opisthorchiasis, 40 with
psoriasis without
helminthiasis, and 30 with chronic
opisthorchiasis, and 15 healthy individuals were examined. To evaluate the pancreas, its incretory and excretory functions were studied. In patients with
psoriasis concurrent with chronic
opisthorchiasis, the pancreatic level of
hormones and
enzymes was significantly lower than those in patients with
psoriasis without
helminthiasis. Twelve months after dehelminthization, a follow-up of the parameters of the incretory function revealed their significant increase in 43 patients. Following dehelminthization, the excretory function in terms of
amylase and
lipase was significantly greater than that before dehelminthization. By taking into account
steatorrhea, pancreatic excretory dysfunction showed significantly less fecal fat losses after a course of anthelminthic
therapy. Malabsorption diminished in patients after anthelminthic
therapy, as confirmed by increased urinary
D-xylose excretion. Pancreatic proteolytic activity improved after dehelminthization, as supported by a significant increase in urinary
PABA excretion. No improvement was observed in patients receiving no anthelminthic
therapy; on the contrary, deterioration was established in half of them. Therefore, a year after dehelminthization, helminthological cure in patients with
psoriasis concurrent with chronic
opisthorchiasis causes a significant improvement in pancreatic incretory and excretory functions and promotes regression of psoriatic manifestation.