The only curative treatment in
biliary tract cancer is surgical treatment. Therefore, the suitability of curative resection should be investigated in the first place. In the presence of
metastasis to the liver, lung, peritoneum, or distant lymph nodes, curative resection is not suitable. No definite consensus has been reached on local extension factors and curability. Measures of hepatic functional reserve in the jaundiced liver include future liver remnant volume and the
indocyanine green (ICG) clearance test. Preoperative portal vein embolization may be considered in patients in whom right
hepatectomy or more, or
hepatectomy with a resection rate exceeding 50%-60% is planned. Postoperative complications and surgery-related mortality may be reduced with the use of portal vein embolization. Although
hepatectomy and/or
pancreaticoduodenectomy are preferable for the curative resection of
bile duct cancer, extrahepatic bile duct resection alone is also considered in patients for whom it is judged that curative resection would be achieved after a strict diagnosis of its local extension. Also, combined caudate lobe resection is recommended for
hilar cholangiocarcinoma. Because the prognosis of patients treated with combined portal vein resection is significantly better than that of unresected patients, combined portal vein resection may be carried out. Prognostic factors after resection for
bile duct cancer include
positive surgical margins, especially in the ductal stump;
lymph node metastasis; perineural invasion; and combined vascular resection due to portal vein and/or hepatic artery invasion. For patients with suspected
gallbladder cancer,
laparoscopic cholecystectomy is not recommended, and open
cholecystectomy should be performed as a rule. When
gallbladder cancer invading the subserosal layer or deeper has been detected after simple
cholecystectomy, additional resection should be considered. Prognostic factors after resection for
gallbladder cancer include the depth of mural invasion;
lymph node metastasis; extramural extension, especially into the hepatoduodenal ligament; perineural invasion; and the degree of curability.
Pancreaticoduodenectomy is indicated for ampullary
carcinoma, and limited operation is also indicated for
carcinoma in
adenoma. The prognostic factors after resection for ampullary
carcinoma include
lymph node metastasis, pancreatic invasion, and perineural invasion.