Abstract | OBJECTIVE AND METHOD: RESULTS: Following 6 hours of transient ischemia and reperfusion, MABP was decreased by about 10 or 20% as compared to the baseline MABP with low-dose or high-dose nicardipine administration, respectively. ICP was significantly increased following reperfusion, although it did not increase further with nicardipine infusion. CONCLUSION: Under conditions where ICP was high following reperfusion, nicardipine reduced blood pressure safely without increasing ICP in rats.
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Authors | Toshinori Matsuzaki, Tsuneo Kano, Yoichi Katayama, Shin Nakamura, Tadashi Harada |
Journal | Neurological research
(Neurol Res)
Vol. 30
Issue 5
Pg. 531-5
(Jun 2008)
ISSN: 0161-6412 [Print] England |
PMID | 18241526
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium Channel Blockers
- Nicardipine
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Topics |
- Analysis of Variance
- Animals
- Blood Pressure
(drug effects)
- Brain Infarction
(etiology, prevention & control)
- Calcium Channel Blockers
(therapeutic use)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Intracranial Pressure
(drug effects)
- Ischemic Attack, Transient
(drug therapy, physiopathology)
- Male
- Nicardipine
(therapeutic use)
- Rats
- Rats, Inbred SHR
- Reperfusion
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